WebAug 13, 2024 · In Arabidopsis, AtEH/Pan1 proteins play a dual role, where on one hand, they drive actin-mediated autophagy, and on the other hand, they bind auxiliary endocytic adaptors as well as the plasma membrane (Wang et al., 2024; Yperman et al., 2024). WebMar 17, 2024 · Here we used live-cell imaging and biochemical approaches to investigate the function of the Arabidopsis thaliana TPC subunit AtEH1/Pan1. Using in vitro and in …
Articles in 2024 Nature Communications
WebJan 28, 2024 · Moreover, AtEHs/Pan1-regulated autophagosomes associate with ER-PM contact sites (EPCS) where AtEH1/Pan1 interacts with VAP27-1. Knock-down expression of either AtEH1/Pan1 or VAP27-1 makes plants more susceptible to nutrient depleted conditions, indicating that the autophagy pathway is perturbed. In conclusion... WebThe Arabidopsis EH proteins (AtEH1/Pan1 and AtEH2/Pan1) are components of the endocytic TPLATE complex (TPC) which is essential for endocytosis. Both proteins are … black pearl software factory
RCSB PDB - 6YET: Second EH domain of AtEH1/Pan1
WebMar 18, 2024 · Clathrin-mediated endocytosis (CME) is an essential cellular internalisation pathway involving the dynamic assembly of clathrin and accessory proteins to form … WebSep 1, 2024 · AtEH1/Pan1 contains a typical VCA motif, which is responsible for ARP2/3 activation; it is able to bind to actin filaments and interact with APR2/3 subunits, suggesting a similar NPF function in plants. AtEH/Pan1 localizes to autophagosomes and promotes endosome to autophagosome conversion (Figure 2 B). WebIn particular, two TPC members, AtEH1/Pan1 and AtEH2/Pan1 play an important role in this pathway (Figure 8) and several components of the endocytic machinery are associated with this pathway, either as machinery or as cargo. Ongoing research focusses on unravelling in detail how this pathway is initiated, as well as how it is connected to the ... black pearl solar company