Biofilm and rifampin
WebJun 26, 2015 · Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria. Understanding the distribution, expression, and physiological functions of multidrug efflux pumps, especially under physiologically and clinically relevant conditions of the pathogens, is the key to combat drug resistance. In … WebDapsone and rifampin, both have been shown to have an effect on borrelial biofilms, as per a study with did with Dr Eva Sapi's group from the Univ of New Haven. Horowitz, R.I., Murali, K., Gaur, G. et al. Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi. BMC Res Notes 13, 455 ...
Biofilm and rifampin
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Webefficiency of azithromycin or rifampin plus other antibi-otics against stationary phase and B. henselae biofilms. Our study was the first to evaluate drug combinations against B. henselae non-growing stationary phase bac-teria and biofilms and could provide experimental basis for further clinical evaluation. Results WebAug 19, 2024 · Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative ‘outside of the box’ therapeutics.
WebOct 1, 2009 · Rifampin is reported to enhance the activity of vancomycin against S. aureus in biofilm [12, 32] and against S. aureus that have been ingested by polymorphonuclear leukocytes . In addition, subinhibitory concentrations of rifampin inhibit PVL production by S. aureus [ 24 ]. WebJan 17, 2012 · The P. acnes minimal biofilm eradication concentration (MBEC) was 16 μg/ml for rifampin; 32 μg/ml for penicillin G; 64 μg/ml for daptomycin and ceftriaxone; and ≥128 μg/ml for levofloxacin ...
WebJun 13, 2024 · This is a case series of 10 patients who had staphylococcal biofilm infections that were treated with adjuvant rifabutin therapy instead of rifampin therapy. In these cases, rifampin was contraindicated secondary to drug–drug interactions with the patients’ chronic medications. Rifabutin therapy was well tolerated with no side … WebJun 29, 2009 · The purpose of this study was to quantify the biofilm formation of S. aureus isolates obtained from patients with SAIE, to assess the in vitro activities of daptomycin and vancomycin alone and in combination with rifampin or gentamicin, and to evaluate the development of resistance in a high-inoculum, stationary-phase bacterial (biofilm) model ...
WebSep 21, 2024 · Rifampin is one of the most important biofilm-active antibiotics in the treatment of periprosthetic joint infection (PJI), and antibiotic regimens not involving rifampin were shown to have higher failure rates. Therefore, an emerging rifampin resistance can have a devastating effect on the outcome of PJI. The aim of this study …
WebFeb 14, 2014 · This chapter discusses biofilm formation in enterococci and its role in the biology of these organisms, especially in relation to opportunistic infections. As is the case for many microbes, the pace of enterococcal biofilm research has quickened in the past few years, and numerous genes and gene products affecting biofilm formation have been … portland adventist home healthWebFeb 18, 2014 · Fosfomycin may be used in combination with rifampin against MRSA implant-associated infections, but it cannot replace rifampsin as an antibiofilm agent. ABSTRACT Increasing antimicrobial resistance reduces treatment options for implant-associated infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We … portland adventist imagingNational Center for Biotechnology Information portland adventist health jobsWebIt has been shown that Rif diffuses well into biofilm where it acts to kill biofilm-associated bacteria. 31 Rifampin-resistant mutants may be selected, so guidelines suggest that rifampin should be used in conjunction with other antibiotics. 31 In this study, ciprofloxacin (Cipro), a 2nd generation fluoroquinolone, was selected for proven ... optical merchandisingWebMar 8, 2024 · Despite the discovery of antibiotics, the battle against bacteria is so far in their favor, specifically because bugs are able to develop a superstructure named biofilm, to resist and to survive in the environment. Nosocomial infections, a major health problem, are due at 80% to biofilm‐associated infection, and Staphylococcus aureus is the leading … optical mesh networkWebNational Center for Biotechnology Information portland adventist hospital portland orWebApr 1, 2024 · This review addresses biofilm formation and recent insights of the organisms involved in biofilm-related implant infections; how composition of microbiomes from skin, nasopharyngeal, and nearby tissue can impactBiofilm-formation, and infection; the role of the gut microbiome in implant-relatedBiofilm formation; and therapeutic strategies to … optical mesh