WebbRecent studies suggest that central nervous system synapses can persist for weeks, months, perhaps lifetimes, yet little is known as to how synapses maintain t Webb这是第一个破译 sno 相关共享机制的研究 还检测到受 sno 影响并在两种小鼠模型之间共享的其他分子改变，例如突触相关过程、pka 信号传导和细胞骨架相关过程。这是第一个破译 sno 相关共享机制的研究shank3和mapt突变。
CaMKII: a central molecular organizer of synaptic plasticity, …
Webb7 okt. 2011 · Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic … Webb26 mars 2024 · Shank3, a master postsynaptic scaffolding protein that controls the developmental maturation of excitatory synapses, was recently shown … Protein-protein … cycling event malaysia 2022
SHANK family on stem cell fate and development
Webb22 maj 2024 · Shank3 is a highly phosphorylated protein Phosphorylation is one of the most common regulatory mechanisms to modulate synaptic protein interactions and subcellular localization. Since SHANK3 is a large essential scaffolding protein in the PSD, we sought to investigate phosphorylation-mediated SHANK3 regulation. Webb7 okt. 2011 · Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific functions have not been clearly demonstrated. WebbShank1 and Shank3 contain several RSK consensus phosphorylation sites (RXRXXS, where X is any amino acid) and both Shanks were efficiently phosphorylated by RSK2 in vitro (data not shown). Indeed, RSK2 phosphorylated Shank1 (368–932) with a K m value (0.17 μM) far below that for the S6 peptide (9.6 μM), a standard RSK2 in vitro substrate, … cheap wine tours in florence italy