The role of jak2a in zebrafish hematopoiesis
WebbJanus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2617V>F) is associated with myeloproliferative diseases, particularly polycythemia vera. ... The role of jak2a in zebrafish hematopoiesis. Ma A; Ward A; Liang R; et al. See more; Blood (2007) 110(6) 1824-1830. DOI: 10.1182/blood-2007-03 ... Webb1 juni 2007 · The role of jak2a in zebrafish hematopoiesis. Abstract. Janus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation …
The role of jak2a in zebrafish hematopoiesis
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Webb1 okt. 2007 · Janus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2 (617V>F)) is associated with myeloproliferative … WebbJanus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2(617V>F)) is associated with myeloproliferative diseases, particularly polycythemia vera. In this study, we examined the role of jak2a in zebrafish embryos in knock-down and overexpression studies using morpholinos (MOs) targeting …
WebbWe recently reported the use of zebrafish to evaluate the hematopoietic function of isocitrate dehydrogenase 1 ( IDH1) and the effects of expressing human IDH1-R132H that is frequently identified in human acute myeloid leukemia (AML), in myelopoiesis, with a view to develop zebrafish as a model of AML. Webb14 sep. 2007 · In this study, we examined the role of jak2a in zebrafish embryos in knock-down and overexpression studies using morpholinos (MOs) targeting the 5\u27 …
Webb1 apr. 2024 · Peripheral blood JAK2 V617F+ granulocytes had higher surface expression of MICB but did not differ in the amount of MICA and MICB transcripts from normal granulocytes. MICA and MICB genes were significantly down-regulated in JAK2 V617F+ CD34+ cells from primary myelofibrosis patients in comparison to normal CD34+ … Webblink_to_OA_fulltext. File Download. re01.htm Links for fulltext
Webb16 jan. 2009 · Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematologic malignancies. A somatic mutation of …
Webbhematopoiesis [15]. Furthermore, the role of jak2a in hematopoiesis was subsequently studied with qualitative and quantitative analyses using morpholino (MO) knockdown, which revealed that erythrocytosis in zebrafish embryos is mediated by jak2a activation [9]. Subsequently, V581F, jak2awhich is an ortholog of the human V617F mutation, was JAK2 eebk モーターWebb18 juli 2024 · Zebrafish (Danio rerio) are an attractive vertebrate model for the molecular dissection of disease mechanisms. Janus kinase (JAK)/signal transducer and activator … ee-db50 クエン酸洗浄WebbThe role of jak2a in zebrafish hematopoiesis. Authors: Ma AC, Ward AC, Liang R, Leung AY. Citation: Blood. 2007 Sep 15;110(6):1824-30. Epub 2007 Jun 1 ... eeaとは イギリスWebbFör 1 dag sedan · Hematopoiesis is the process of blood generation that starts during development in several waves. The primitive wave gives rise to unipotent blood cells, mostly erythroid and myeloid cells. The ... eea 加盟国 イギリスWebb8 aug. 2024 · The most common mutation within the JAK2 gene is JAK2-V617F that leads to constitutive activation of the kinase and thereby aberrant engagement of downstream … eebq モーターWebb15 sep. 2007 · Zebrafish jak2a is involved in primitive hematopoiesis under normal and deregulated conditions. Janus kinase 2 (Jak2) transduces signals from hematopoietic … eedb-1610 カタログWebb19 feb. 2024 · Recently, mutations in the gene encoding ribosomal protein (RP) L18 were identified in DBA patients. RPL18 is a crucial component of the ribosomal large subunit but its role in hematopoiesis remains unknown. To genetically model the ribosomal defect identified in DBA, we generated a rpl18 mutant line in zebrafish, using CRISPR/Cas9 … eecとは タイ